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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: USP14 All Species: 28.79
Human Site: Y401 Identified Species: 42.22
UniProt: P54578 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54578 NP_001032411.1 494 56069 Y401 S P Q K E V K Y E P F S F A D
Chimpanzee Pan troglodytes P60051 493 55922 Y401 S P Q K E V K Y E P F S F A D
Rhesus Macaque Macaca mulatta XP_001090667 458 52239 F369 K E V K Y E P F S F A D D I G
Dog Lupus familis XP_537306 545 61461 Y452 S P Q K E V K Y E P F S F A D
Cat Felis silvestris
Mouse Mus musculus Q9JMA1 493 55983 Y400 S P P K E I K Y E P F S F A D
Rat Rattus norvegicus NP_001008302 493 55958 Y400 S P P K E I K Y E P F S F A D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519267 431 48760 S342 E V K Y E P F S F P D D I G S
Chicken Gallus gallus XP_419150 492 55612 Y399 G A Q K E V K Y E P F S F P D
Frog Xenopus laevis Q6GNI6 523 60030 K398 T K Q L T M K K L P I V A C F
Zebra Danio Brachydanio rerio A6H8I0 506 58102 P410 I T T Y V S F P L E L D M T P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609377 475 53689 D385 E P N E E K K D V K Y E Q F W
Honey Bee Apis mellifera XP_395043 497 56311 Q398 D S K K K V K Q E S F W F P D
Nematode Worm Caenorhab. elegans Q17361 489 55859 A375 K I F D D G V A L P T A F E D
Sea Urchin Strong. purpuratus XP_786966 516 58357 Y412 E P K K D V K Y L P Y D F P D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q949Y0 482 53677 T380 K D S D V K M T D A E A S A N
Baker's Yeast Sacchar. cerevisiae P43593 499 57092 T396 T P R E Q Y E T Q V A L N E S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 92.5 89.9 N.A. 96.7 96.5 N.A. 80.3 90.4 21.4 20.1 N.A. 54.6 61.7 41.9 61
Protein Similarity: 100 99.8 92.7 90.2 N.A. 98.5 98.7 N.A. 83.8 94.9 39 38.7 N.A. 71.2 80.2 61.1 76.5
P-Site Identity: 100 100 6.6 100 N.A. 86.6 86.6 N.A. 13.3 80 20 0 N.A. 20 46.6 20 53.3
P-Site Similarity: 100 100 13.3 100 N.A. 93.3 93.3 N.A. 20 80 33.3 0 N.A. 33.3 60 33.3 73.3
Percent
Protein Identity: N.A. N.A. N.A. 43.5 26 N.A.
Protein Similarity: N.A. N.A. N.A. 62.9 46.2 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 0 0 7 0 7 13 13 7 38 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % C
% Asp: 7 7 0 13 13 0 0 7 7 0 7 25 7 0 57 % D
% Glu: 19 7 0 13 50 7 7 0 44 7 7 7 0 13 0 % E
% Phe: 0 0 7 0 0 0 13 7 7 7 44 0 57 7 7 % F
% Gly: 7 0 0 0 0 7 0 0 0 0 0 0 0 7 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 7 0 0 0 13 0 0 0 0 7 0 7 7 0 % I
% Lys: 19 7 19 57 7 13 63 7 0 7 0 0 0 0 0 % K
% Leu: 0 0 0 7 0 0 0 0 25 0 7 7 0 0 0 % L
% Met: 0 0 0 0 0 7 7 0 0 0 0 0 7 0 0 % M
% Asn: 0 0 7 0 0 0 0 0 0 0 0 0 7 0 7 % N
% Pro: 0 50 13 0 0 7 7 7 0 63 0 0 0 19 7 % P
% Gln: 0 0 32 0 7 0 0 7 7 0 0 0 7 0 0 % Q
% Arg: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 32 7 7 0 0 7 0 7 7 7 0 38 7 0 13 % S
% Thr: 13 7 7 0 7 0 0 13 0 0 7 0 0 7 0 % T
% Val: 0 7 7 0 13 38 7 0 7 7 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 7 % W
% Tyr: 0 0 0 13 7 7 0 44 0 0 13 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _